296280-56-3

296280-56-3 structure

Name: S26131
Chemical Name: S26131
CAS Number: 296280-56-3
Molecular Formula: C₃₁H₃₄N₂O₄
Molecular Weight: 498.61
Catalog: Signaling Pathways GPCR/G Protein Melatonin Receptor
Create Date: 2020-01-23 13:04:51
Modify Date: 2024-01-23 23:03:48
S26131 (compound 5) is a potent and selective MT1 melatoninergic ligand, and the Ki values are 0.5 and 112 nM for MT1 and MT2, respectively. S26131 behaves as an MT1 and MT2 antagonist[1].

Name	S26131

Description	S26131 (compound 5) is a potent and selective MT1 melatoninergic ligand, and the Ki values are 0.5 and 112 nM for MT1 and MT2, respectively. S26131 behaves as an MT1 and MT2 antagonist[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Melatonin Receptor Signaling Pathways >> GPCR/G Protein >> Melatonin Receptor Research Areas >> Neurological Disease
In Vitro	S26131 behaves as an antagonist on MT1 and MT2 receptors with KB values of 5.32 and 143 nM, respectively[1].
References	[1]. Descamps-François C, et al. Design and synthesis of naphthalenic dimers as selective MT1 melatoninergic ligands. J Med Chem. 2003 Mar 27;46(7):1127-9.