1083433-49-1

1083433-49-1 structure

Name: S961
Chemical Name: S961
CAS Number: 1083433-49-1
Molecular Formula: C₂₁₁H₂₉₇N₅₅O₇₁S₂
Molecular Weight: 4804.13
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK Insulin Receptor
Create Date: 2020-01-23 09:16:51
Modify Date: 2024-01-03 01:19:23
S961 is an high-affinity and selective insulin receptor (IR) antagonist with IC50s of 0.048, 0.027, and 630 nM for HIR-A, HIR-B, and human insulin-like growth factor I receptor (HIGF-IR) in SPA-assay, respectively[1].

Name	S961

Description	S961 is an high-affinity and selective insulin receptor (IR) antagonist with IC50s of 0.048, 0.027, and 630 nM for HIR-A, HIR-B, and human insulin-like growth factor I receptor (HIGF-IR) in SPA-assay, respectively[1].
Related Catalog	Research Areas >> Metabolic Disease Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Insulin Receptor
In Vitro	S961 also shows high-affinity to Rat IR and Pig IR with IC50s of 0.056 nM and 0.084 nM in PEG-assay, respectively[1].
References	[1]. Schäffer L, et al. A novel high-affinity peptide antagonist to the insulin receptor. Biochem Biophys Res Commun. 2008 Nov 14;376(2):380-3.

RIDADR	NONH for all modes of transport