2227246-92-4

2227246-92-4 structure

Name: 2,5-Dioxopyrrolidin-1-yl 1-(9H-fluoren-9-yl)-3-oxo-2,7,10,13,16,19,22,25,28,31,34,37,40-tridecaoxa-4-azatritetracontan-43-oate
Chemical Name: Fmoc-PEG12-NHS ester
CAS Number: 2227246-92-4
Molecular Formula: C₄₆H₆₈N₂O₁₈
Molecular Weight: 937.03
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2020-06-01 12:17:55
Modify Date: 2024-01-12 18:40:45
Fmoc-PEG12-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	Fmoc-PEG12-NHS ester

Description	Fmoc-PEG12-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs Alkyl/ether
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Molecular Formula	C₄₆H₆₈N₂O₁₈
Molecular Weight	937.03