1254044-41-1

1254044-41-1 structure

Name: Mito-apocynin (C2)
Chemical Name: Mito-apocynin (C2)
CAS Number: 1254044-41-1
Molecular Formula: C₂₈H₂₇BrNO₃P
Molecular Weight: 536.40
Catalog: Research Areas Neurological Disease
Create Date: 2020-06-01 12:39:25
Modify Date: 2024-01-31 17:41:00
Mito-apocynin (C2), an orally active mitochondria-targeted triphenylphosphonium (TPP)-based compound, is synthesized by conjugating the Apocynin moiety with a TPP + cation. Mito-apocynin (C2) exhibits antineuroinflammatory effect[1].

Name	Mito-apocynin (C2)

Description	Mito-apocynin (C2), an orally active mitochondria-targeted triphenylphosphonium (TPP)-based compound, is synthesized by conjugating the Apocynin moiety with a TPP + cation. Mito-apocynin (C2) exhibits antineuroinflammatory effect[1].
Related Catalog	Research Areas >> Neurological Disease
In Vivo	Mito-apocynin (C2) (3 mg/kg; p.o.; daily for 12 days) exhibits antineuroinflammatory effect[1]. Animal Model: MPTP mice model of Parkinson’s Disease[1] Dosage: 3 mg/kg Administration: Oral gavage; daily for 12 days Result: Significantly attenuated MPTP-induced glial cell activation, proinflammatory cytokine upregulation, inducible nitric oxide synthase, and NOX2 components (gp91phox).
References	[1]. Zielonka J, et al. Mitochondria-Targeted Triphenylphosphonium-Based Compounds: Syntheses, Mechanisms of Action, and Therapeutic and Diagnostic Applications. Chem Rev. 2017 Aug 9;117(15):10043-10120.

Molecular Formula	C₂₈H₂₇BrNO₃P
Molecular Weight	536.40