353487-64-6

353487-64-6 structure

Name: Ac-Arg-Cys-Met-5-aminopentanoyl-Arg-Val-Tyr-5-aminopentanoyl-Cys-NH2 trifluoroacetate salt (Disulfide bond)
Chemical Name: Ac-Arg-Cys-Met-5-aminopentanoyl-Arg-Val-Tyr-5-aminopentanoyl-Cys-NH2 trifluoroacetate salt (Disulfide bond)
CAS Number: 353487-64-6
Molecular Formula: C₄₉H₈₂N₁₆O₁₁S₃
Molecular Weight: 1167.471
Catalog: Signaling Pathways GPCR/G Protein MCHR1 (GPR24)
Create Date: 2021-01-07 16:43:38
Modify Date: 2024-07-22 15:01:30
hMCH-1R antagonist 1 (Compound 30) is an effective and selective antagonist of human melanin-concentrating hormone receptor 1 (hMCHR1) with an KB value of 3.6 nM. HMCH-1R antagonist 1 can bind to hMCHR1 and hMCHR2 with IC50 values of 65 nM and 49 nM, respectively. HMCH-1R antagonistist 1 can be used for metabolic research[1].

Name	Ac-Arg-Cys-Met-5-aminopentanoyl-Arg-Val-Tyr-5-aminopentanoyl-Cys-NH2 trifluoroacetate salt (Disulfide bond)
Synonyms	(4R,13S,16S,19S,28S,31R)-31-[(N2-Acetyl-L-arginyl)amino]-19-(3-carbamimidamidopropyl)-13-(4-hydroxybenzyl)-16-isopropyl-28-[2-(methylsulfanyl)ethyl]-6,12,15,18,21,27,30-heptaoxo-1,2-dithia-5,11,14,1 7,20,26,29-heptaazacyclodotriacontane-4-carboxamide 1,2-Dithia-5,11,14,17,20,26,29-heptaazacyclodotriacontane-4-carboxamide, 31-[[(2S)-2-(acetylamino)-5-[(aminoiminomethyl)amino]-1-oxopentyl]amino]-19-[3-[(aminoiminomethyl)amino]propyl]-13-[(4-hydroxyphenyl)methyl]-16-(1-methylethyl)-28-[2-(methylthio)ethyl]-6,12,15,18,21,27,30-heptaoxo-, (4R,13S,16S,19S,28S,31R)-

Description	hMCH-1R antagonist 1 (Compound 30) is an effective and selective antagonist of human melanin-concentrating hormone receptor 1 (hMCHR1) with an KB value of 3.6 nM. HMCH-1R antagonist 1 can bind to hMCHR1 and hMCHR2 with IC50 values of 65 nM and 49 nM, respectively. HMCH-1R antagonistist 1 can be used for metabolic research[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> MCHR1 (GPR24) Research Areas >> Metabolic Disease
References	[1]. Bednarek MA, et al. Synthesis and biological evaluation in vitro of selective, high affinity peptide antagonists of human melanin-concentrating hormone action at human melanin-concentrating hormone receptor 1. Biochemistry. 2002 May 21;41(20):6383-90.