444073-04-5

444073-04-5 structure

Name: (D-Ala2)-Gastric Inhibitory Polypeptide (human) trifluoroacetate salt
Chemical Name: (D-Ala2)-Gastric Inhibitory Polypeptide (human) trifluoroacetate salt
CAS Number: 444073-04-5
Molecular Formula: C₂₂₆H₃₃₈N₆₀O₆₆S
Molecular Weight:
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK Insulin Receptor
Create Date: 2021-01-07 18:38:43
Modify Date: 2024-01-17 17:58:22
[D-Ala2]-GIP (human) is a GIP receptor agonist. [D-Ala2]-GIP (human) improves glucose tolerance. [D-Ala2]-GIP (human) shows neuroprotective activity in MPTP-induced Parkinson's disease model. [D-Ala2]-GIP (human) also improves cognitive function and hippocampal synaptic plasticity in obese diabetic rats. [D-Ala2]-GIP (human) can be used for research of type 2 diabetes, Parkinson's disease, etc[1]

Name	(D-Ala2)-Gastric Inhibitory Polypeptide (human) trifluoroacetate salt

Description	[D-Ala2]-GIP (human) is a GIP receptor agonist. [D-Ala2]-GIP (human) improves glucose tolerance. [D-Ala2]-GIP (human) shows neuroprotective activity in MPTP-induced Parkinson's disease model. [D-Ala2]-GIP (human) also improves cognitive function and hippocampal synaptic plasticity in obese diabetic rats. [D-Ala2]-GIP (human) can be used for research of type 2 diabetes, Parkinson's disease, etc[1]
Related Catalog	Research Areas >> Metabolic Disease Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Insulin Receptor Research Areas >> Neurological Disease
References	[1]. Hinke SA, et al. Dipeptidyl peptidase IV-resistant [D-Ala(2)]glucose-dependent insulinotropic polypeptide (GIP) improves glucose tolerance in normal and obese diabetic rats. Diabetes. 2002 Mar;51(3):652-61. [2]. Porter DW,et al. Prolonged GIP receptor activation improves cognitive function, hippocampal synaptic plasticity and glucose homeostasis in high-fat fed mice. Eur J Pharmacol. 2011 Jan 15;650(2-3):688-93. [3]. Verma MK, et al. Effect of D-Ala2GIP, a stable GIP receptor agonist on MPTP-induced neuronal impairments in mice. Eur J Pharmacol. 2017 Jun 5;804:38-45.

Molecular Formula	C₂₂₆H₃₃₈N₆₀O₆₆S