1609564-75-1

1609564-75-1 structure

Name: DY268
Chemical Name: DY 268
CAS Number: 1609564-75-1
Molecular Formula: C₃₀H₃₂N₄O₅S
Molecular Weight: 560.664
Catalog: Signaling Pathways Metabolic Enzyme/Protease FXR
Create Date: 2021-01-12 18:26:39
Modify Date: 2024-04-06 13:26:12
DY268 is a farnesoid X receptor (FXR) antagonist (IC50=7.5 nM in a time-resolved FRET assay). It inhibits FXR transactivation in a cell-based assay with an IC50 value of 468 nM[1].

Name	DY 268
Synonyms	DY 268 1H-Pyrazole-4-carboxamide, 1-[(3-methoxyphenyl)methyl]-N-[4-methyl-3-(4-morpholinylsulfonyl)phenyl]-3-(4-methylphenyl)- 1-(3-Methoxybenzyl)-N-[4-methyl-3-(4-morpholinylsulfonyl)phenyl]-3-(4-methylphenyl)-1H-pyrazole-4-carboxamide

Description	DY268 is a farnesoid X receptor (FXR) antagonist (IC50=7.5 nM in a time-resolved FRET assay). It inhibits FXR transactivation in a cell-based assay with an IC50 value of 468 nM[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> FXR Research Areas >> Metabolic Disease
References	[1]. Yu DD, Lin W, Forman BM, Chen T. Identification of trisubstituted-pyrazol carboxamide analogs as novel and potent antagonists of farnesoid X receptor. Bioorg Med Chem. 2014 Jun 1;22(11):2919-38.