1998197-39-9

1998197-39-9 structure

Name: ZCZ011
Chemical Name: ZCZ-011
CAS Number: 1998197-39-9
Molecular Formula: C₂₁H₁₈N₂O₂S
Molecular Weight: 362.44
Catalog: Signaling Pathways GPCR/G Protein Cannabinoid Receptor
Create Date: 2021-01-09 16:25:04
Modify Date: 2024-01-18 12:28:26
ZCZ011 is a potent and brain penetrant cannabinoid 1 (CB1) receptor positive allosteric modulator. ZCZ011 potentiates binding of CP55,940 to the CB1 receptor, enhances anandamide (AEA)-stimulated GTPγS binding in mouse brain membranes. ZCZ011 increases β-arrestin recruitment and ERK phosphorylation in hCB1 cells. ZCZ011 can be used for researching neuropathic and inflammatory pain[1].

Name	ZCZ-011
Synonyms	ZCZ011 1H-Indole, 6-methyl-3-[2-nitro-1-(2-thienyl)ethyl]-2-phenyl- ZCZ-011 6-Methyl-3-[2-nitro-1-(2-thienyl)ethyl]-2-phenyl-1H-indole

Description	ZCZ011 is a potent and brain penetrant cannabinoid 1 (CB1) receptor positive allosteric modulator. ZCZ011 potentiates binding of CP55,940 to the CB1 receptor, enhances anandamide (AEA)-stimulated GTPγS binding in mouse brain membranes. ZCZ011 increases β-arrestin recruitment and ERK phosphorylation in hCB1 cells. ZCZ011 can be used for researching neuropathic and inflammatory pain[1].
Related Catalog	Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Cannabinoid Receptor
Target	CB1[1]
References	[1]. Ignatowska-Jankowska BM, et al. A Cannabinoid CB1 Receptor-Positive Allosteric Modulator Reduces Neuropathic Pain in the Mouse with No Psychoactive Effects. Neuropsychopharmacology. 2015;40(13):2948-2959.

Hazard Codes	Xi