2254605-76-8
2254605-76-8 structure
- Name: MD001
- Chemical Name: MD001
- CAS Number: 2254605-76-8
- Molecular Formula: C25H18O5
- Molecular Weight: 398.407
- Create Date: 2021-01-09 18:22:16
- Modify Date: 2024-01-06 22:19:31
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MD001 is a dual agonist of peroxisome proliferator-activated receptor α (PPARα) and PPARγ. It binds to PPARα and PPARγ but does not bind to PPARβ/δ. It increases transcriptional activity of PPARα and PPARγ and glucose consumption. MD001 decreases levels of glucose, insulin, free fatty acids, triglycerides, LDL, alanine aminotransferase (ALT), and aspartate aminotransferase (AST) in blood and reduces the size and number of hepatic lipid droplets in diabetic db/db mice.
| Name | MD001 |
|---|---|
| Synonyms |
2H-1-Benzopyran-2-one, 5,7-dihydroxy-8-methyl-3-[(2E)-1-oxo-3-phenyl-2-propen-1-yl]-4-phenyl-
MD001 5,7-Dihydroxy-8-methyl-4-phenyl-3-[(2E)-3-phenyl-2-propenoyl]-2H-chromen-2-one |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 575.1±45.0 °C at 760 mmHg |
| Molecular Formula | C25H18O5 |
| Molecular Weight | 398.407 |
| Flash Point | 199.1±22.2 °C |
| Exact Mass | 398.115417 |
| LogP | 6.14 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.704 |