Shanghai Nianxing Industrial Co., Ltd
China
Product Name: IP7e
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Huang

DC Chemicals Limited
China
Product Name: IP7e
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
Purity: 98.0%
Stocking Period: 1 Day
Contact: Tony Cao

500164-74-9

500164-74-9 structure

500164-74-9 structure

Name: IP7e
Chemical Name: IP7e
CAS Number: 500164-74-9
Molecular Formula: C₂₃H₂₂N₂O₄
Molecular Weight: 390.43
Catalog: Research Areas Inflammation/Immunology
Create Date: 2021-09-03 15:13:57
Modify Date: 2024-01-08 18:00:30
IP7e is a potent, brain-penetrant and orally active Nurr1 activator with an EC50 value of 3.9 nM[1].

Name	IP7e
Synonyms	6-{4-[(2-Methoxyethoxy)methyl]phenyl}-5-methyl-3-phenyl[1,2]oxazolo[4,5-c]pyridin-4(5H)-one IP7e MFCD30182349 Isoxazolo[4,5-c]pyridin-4(5H)-one, 6-[4-[(2-methoxyethoxy)methyl]phenyl]-5-methyl-3-phenyl-

Description	IP7e is a potent, brain-penetrant and orally active Nurr1 activator with an EC50 value of 3.9 nM[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
Target	EC50: 3.9 nM (Nurr1)[1]
In Vivo	IP7e (Isoxazolo-pyridinone 7e; 10 mg/kg; oral gavage; twice a day) preventive treatment reduces the incidence and the severity of a MS murine model, i.e. experimental autoimmune encephalomyelitis (EAE). IP7e attenuates inflammation and neurodegeneration in spinal cords of EAE mice by an NF-kB pathway-dependent process[2]. Animal Model: Female C57BL/6J mice (6-8 week-old) with experimental autoimmune encephalomyelitis (EAE)[2]. Dosage: 10 mg/kg Administration: Oral gavage; twice a day; preventive administration (before the disease onset) from 7 to 23 d.p.i. and therapeutic (after the disease onset) from 21 to 36 d.p.i. Result: Preventive administration delayed the onset and reduces the incidence and severity of EAE, and decreased neuroinflammatory and histopathological alterations in the spinal cord of treated EAE mice. On the contrary, the course of EAE was not influenced by the therapeutic administration.
References	[1]. Samuel Hintermann, et al. Identification of a series of highly potent activators of the Nurr1 signaling pathway. Bioorg Med Chem Lett. 2007 Jan 1;17(1):193-6. [2]. Francesca Montarolo, et al. Effects of isoxazolo-pyridinone 7e, a potent activator of the Nurr1 signaling pathway, on experimental autoimmune encephalomyelitis in mice. PLoS One. 2014 Sep 29;9(9):e108791.

Density	1.2±0.1 g/cm3
Boiling Point	611.8±55.0 °C at 760 mmHg
Molecular Formula	C₂₃H₂₂N₂O₄
Molecular Weight	390.43
Flash Point	323.8±31.5 °C
Exact Mass	390.157959
LogP	2.61
Vapour Pressure	0.0±1.8 mmHg at 25°C
Index of Refraction	1.593
Storage condition	-20°C