911392-40-0

911392-40-0 structure

Name: 13C15-Nivalenol
Chemical Name: 13C15-Nivalenol
CAS Number: 911392-40-0
Molecular Formula: ₁₃C₁₅H₂₀O₇
Molecular Weight: 327.20
Catalog: Research Areas Infection
Create Date: 2021-04-18 09:00:48
Modify Date: 2024-01-09 21:01:15
Nivalenol-13C15 is the 13C labeled Nivalenol (HY-N6801)[1]. Nivalenol, classified as type B trichotecenes toxins produced by Fusarium graminearum, is a fungal metabolite present in agricultural product[2]. Nivalenol induces cell death through caspase-dependent mechanisms and via the intrinsic apoptotic pathway. Nivalenol affects the immune system, causes emesis, growth retardation, reproductive disorders and has a haematotoxic/myelotoxic effect[3].

Name	13C15-Nivalenol
Synonyms	13C15-Nivalenol Trichothec-9-en-8-one-2,3,4,5,6,7,8,9,10,11,12,13,14,15,16-13C15, 12,13-epoxy-3,4,7,15-tetrahydroxy-, (2α,3α,4β,7α,12α)- (3α,4β,7α)-3,4,7,15-Tetrahydroxy(2,3,4,5,6,7,8,9,10,11,12,13,14,15,16-13C15)-12,13-epoxytrichothec-9-en-8-one

Description	Nivalenol-13C15 is the 13C labeled Nivalenol (HY-N6801)[1]. Nivalenol, classified as type B trichotecenes toxins produced by Fusarium graminearum, is a fungal metabolite present in agricultural product[2]. Nivalenol induces cell death through caspase-dependent mechanisms and via the intrinsic apoptotic pathway. Nivalenol affects the immune system, causes emesis, growth retardation, reproductive disorders and has a haematotoxic/myelotoxic effect[3].
Related Catalog	Research Areas >> Infection
Target	caspase[2]
In Vitro	氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.