166664-90-0

166664-90-0 structure

Name: Yp537
Chemical Name: cys-asn-val-val-pro-leu-tyr(po3h2)-asp-&
CAS Number: 166664-90-0
Molecular Formula: C₆₄H₁₀₄N₁₃O₂₂PS
Molecular Weight:
Catalog: Research Areas Endocrinology
Create Date: 2021-09-09 19:11:33
Modify Date: 2024-01-14 09:26:54
Yp537 is an estrogen receptor (ER) inhibitor that blocks dimerization of the human estrogen receptor[1].

Name	cys-asn-val-val-pro-leu-tyr(po3h2)-asp-&

Description	Yp537 is an estrogen receptor (ER) inhibitor that blocks dimerization of the human estrogen receptor[1].
Related Catalog	Signaling Pathways >> Others >> Estrogen Receptor/ERR Research Areas >> Endocrinology
In Vitro	Yp537 (5-50 μM; 1 h) abolishes the formation of the hER-ERE complex. And dose not inhibit the formation of the STAT1-serum-induced element complex[1]. Yp537 binds to a SH2-like domain, and interferes with the SH2-like phosphopeptide coupling mechanism between hER monomers[1].
References	[1]. Arnold SF, et al. An antiestrogen: a phosphotyrosyl peptide that blocks dimerization of the human estrogen receptor. Proc Natl Acad Sci U S A. 1995 Aug 1;92(16):7475-9.