83968-48-3

83968-48-3 structure

Name: Vasopressin, 8-l-arginine-, monoacetate (salt)
Chemical Name: AVP
CAS Number: 83968-48-3
Molecular Formula: C₄₈H₆₉N₁₅O₁₄S₂
Molecular Weight: 1144.284
Create Date: 2021-09-10 16:40:24
Modify Date: 2024-01-31 21:32:05
Vasopressin acetate is a peptide hormone with vasoconstrictive and antidiuretic activities that binds to the vascular arginine vasopressin receptor, V1, with Kd values of 1.31 and 1.44 nM in A7r5 rat aortic smooth muscle cells and neonatal rat cardiomyocytes, respectively

Name	AVP
Synonyms	[Arg8]Vasopressin acetate 8609690 1-{[(4R,7S,10S,13S,16S,19R)-19-Amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl]carbonyl}-L-prolyl-L-arginylglycinamide acetate (1:1) MFCD00133939 β-Hypophamine Antidiuretic hormone EINECS 204-035-4 [Arg8]-Vasopressin acetate salt Glycinamide, 1-[[(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-13-(phenylmethyl)-1,2-dithia-5,8,11,14,17-pentaazacycloeicos-4-yl]carbonyl]-L-prolyl-L-arginyl-, acetate (1:1) (salt) 1-{[(4R,7S,10S,13S,16S,19R)-19-Amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl]carbonyl}-L-p ;rolyl-N5-(diaminomethylene)-L-ornithylglycinamide acetate (1:1) Argipressin acetate AVP [8-Arginine]Vasopressin acetate Glycinamide, 1-[[(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-13-(phenylmethyl)-1,2-dithia-5,8,11,14,17-pentaazac ;ycloeicos-4-yl]carbonyl]-L-prolyl-N5-(diaminomethylene)-L-ornithyl-, acetate (1:1) (salt)

Description	Vasopressin acetate is a peptide hormone with vasoconstrictive and antidiuretic activities that binds to the vascular arginine vasopressin receptor, V1, with Kd values of 1.31 and 1.44 nM in A7r5 rat aortic smooth muscle cells and neonatal rat cardiomyocytes, respectively
In Vitro	Vasopressin stimulate NKCC2 phosphorylation increase mediated by cAMP-PKA and Ca(2+) signaling in the colon.?The expression and phosphorylation of NKCC2 are increased in the colon by vasopressin stimulation, in association with enhanced activity of the vasopressin/cAMP and Ca(2+) pathways[1].
References	1. Xue H , Tang X . Effect of vasopressin on Na+–K+–2Cl? cotransporter (NKCC) and the signaling mechanisms on the murine late distal colon[J]. European Journal of Pharmacology, 2016, 771:241-246.