949885-90-9

949885-90-9 structure

Name: 2-Methoxyestrone-d4
Chemical Name: Estra-1,3,5(10)-trien-17-one-1,4,16,16-d4, 3-hydroxy-2-methoxy
CAS Number: 949885-90-9
Molecular Formula: C₁₉H₂₀D₄O₃
Molecular Weight: 304.42
Catalog: Research Areas Inflammation/Immunology
Create Date: 2017-02-19 11:19:40
Modify Date: 2024-01-21 17:11:33
2-Methoxyestrone-d4 is the deuterium labeled 2-Methoxyestrone. 2-Methoxyestrone is a methoxylated catechol estrogen and metabolite of estrone, with a pKa of 10.81[1].

Name	Estra-1,3,5(10)-trien-17-one-1,4,16,16-d4, 3-hydroxy-2-methoxy
Synonyms	2-METHOXYESTRONE-D4 2-Methoxyestrone-1,4,16,16-d4

Description	2-Methoxyestrone-d4 is the deuterium labeled 2-Methoxyestrone. 2-Methoxyestrone is a methoxylated catechol estrogen and metabolite of estrone, with a pKa of 10.81[1].
Related Catalog	Research Areas >> Inflammation/Immunology
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Lewis KM, et al. pKa values of estrone, 17 beta-estradiol and 2-methoxyestrone. Steroids. 1979 Nov;34(5):485-99.