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870640-61-2

870640-61-2 structure
870640-61-2 structure
  • Name: (2S,3S)-N-benzyl-1,1-dimethoxy-N,3-dimethylpentan-2-amine
  • Chemical Name: (2S,3S)-N-Benzyl-1,1-dimethoxy-N,3-dimethyl-2-pentanamine
  • CAS Number: 870640-61-2
  • Molecular Formula: C16H27NO2
  • Molecular Weight: 265.391
  • Catalog: Research Areas Cancer
  • Create Date: 2021-09-10 19:52:12
  • Modify Date: 2022-01-14 21:28:07
  • Monomethyl auristatin E intermediate-12 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs)[1].

Name (2S,3S)-N-Benzyl-1,1-dimethoxy-N,3-dimethyl-2-pentanamine
Synonyms Benzenemethanamine, N-[(1S,2S)-1-(dimethoxymethyl)-2-methylbutyl]-N-methyl-
MFCD28385889
(2S,3S)-N-Benzyl-1,1-dimethoxy-N,3-dimethyl-2-pentanamine
Description Monomethyl auristatin E intermediate-12 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs)[1].
Related Catalog
References

[1]. Lisa Buckel, et al. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 1;75(7):1376-87.  

Density 1.0±0.1 g/cm3
Boiling Point 329.1±27.0 °C at 760 mmHg
Molecular Formula C16H27NO2
Molecular Weight 265.391
Flash Point 106.1±10.7 °C
Exact Mass 265.204193
LogP 2.59
Vapour Pressure 0.0±0.7 mmHg at 25°C
Index of Refraction 1.492