6054-10-0

6054-10-0 structure

Name: Braylin
Chemical Name: N'-[(Z)-indol-3-ylidenemethyl]-1-(4-methoxyphenyl)-5-oxopyrrolidine-3-carbohydrazide
CAS Number: 6054-10-0
Molecular Formula: C₁₅H₁₄O₄
Molecular Weight: 258.269
Catalog: Natural product Coumarin
Create Date: 2017-04-29 13:32:52
Modify Date: 2024-01-10 10:26:19
Braylin, a coumarin, is a potent phosphodiesterase-4 (PDE4) inhibitor and is involved in anti-inflammatory and immunomodulation, which may serve as a potential target for the study of immunoinflammatory diseases[1].

Name	N'-[(Z)-indol-3-ylidenemethyl]-1-(4-methoxyphenyl)-5-oxopyrrolidine-3-carbohydrazide
Synonyms	6-methoxyseselin 2H,8H-Benzo[1,2-b:3,4-b']dipyran-2-one, 6-methoxy-8,8-dimethyl- 6-Methoxy-8,8-dimethyl-2H,8H-pyrano[2,3-f]chromen-2-one HMS2622L11

Description	Braylin, a coumarin, is a potent phosphodiesterase-4 (PDE4) inhibitor and is involved in anti-inflammatory and immunomodulation, which may serve as a potential target for the study of immunoinflammatory diseases[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Research Areas >> Inflammation/Immunology
References	[1]. Renan Fernandes Espírito-Santo, et al. The anti-inflammatory and immunomodulatory potential of braylin: Pharmacological properties and mechanisms by in silico, in vitro and in vivo approaches. PLoS One. 2017 Jun 8;12(6):e0179174.

Hazard Codes	Xi
HS Code	2932999099

92-61-5

6054-10-0

Literature: Xie, Lan; Takeuchi, Yasuo; Cosentino, L. Mark; Lee, Kuo-Hsiung Journal of Medicinal Chemistry, 1999 , vol. 42, # 14 p. 2662 - 2672

34191-74-7

6054-10-0

Literature: Xie, Lan; Takeuchi, Yasuo; Cosentino, L. Mark; Lee, Kuo-Hsiung Journal of Medicinal Chemistry, 1999 , vol. 42, # 14 p. 2662 - 2672

1111-97-3

92-61-5

6054-10-0

HS Code	2932999099
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%