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  • DC Chemicals Limited
  • China
  • Product Name: FCCP
  • Price: $250.0/100mg $450.0/250mg $1100.0/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

370-86-5

370-86-5 structure
370-86-5 structure
  • Name: FCCP
  • Chemical Name: carbonyl cyanide p-trifluoromethoxyphenylhydrazone
  • CAS Number: 370-86-5
  • Molecular Formula: C10H5F3N4O
  • Molecular Weight: 254.168
  • Catalog: Chemical reagent Organic reagent
  • Create Date: 2018-06-13 16:46:14
  • Modify Date: 2024-01-03 15:14:07
  • FCCP is an uncoupler of oxidative phosphorylation in mitochondria.

Name carbonyl cyanide p-trifluoromethoxyphenylhydrazone
Synonyms 2-{2-[4-(trifluoromethoxy)phenyl]hydrazono}malononitrile
2-[[4-(trifluoromethoxy)phenyl]hydrazinylidene]propanedinitrile
Propanedinitrile, 2-[2-[4-(trifluoromethoxy)phenyl]hydrazinylidene]-
FCCP,Mesoxalonitrile 4-trifluoromethoxyphenylhydrazone
Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone
Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone
{2-[4-(trifluoromethoxy)phenyl]hydrazinylidene}propanedinitrile
EINECS 206-730-8
{[4-(Trifluoromethoxy)phenyl]hydrazono}malononitrile
MFCD00009699
FCCP
Description FCCP is an uncoupler of oxidative phosphorylation in mitochondria.
Related Catalog
In Vitro FCCP (5 μM) results in a concentration-dependent decrease in Aβ and APPsβ production in K695sw cells. FCCP inhibits processing of wild-type APP. FCCP does not alter cellular ATP levels at any of the concentrations measured. The effects of FCCP on APP catabolism are independent of secondary effects on oxidative phosphorylation or the result of reduced cell viability. FCCP (5 μM or 500 nM), baf A1, and NH4Cl induce changes in Tf-Tx and Tf-F cellular fluorescence in K695 cells[1]. FCCP (200 nM) protects and enhances the follicle integrity in cat ovarian tissue during short-term in vitro culture. But FCCP does not appear to exert a beneficial or detrimental effect during ovarian tissue cryopreservation[2].
Cell Assay K695sw cells are maintained and exposed to vehicle or various concentrations of FCCP as mentioned above with the exception that cells are plated at a density of 20,000 cells per well in 96-well plates. Twenty-four hours after plating, cells are exposed to various treatments in Dulbecco’s modified Eagle’s medium supplemented with sodium pyruvate (1 mM). At the same time as drug exposures, YO-PRO (4 μM) is added to each well, and its uptake is quantified every 30 min for 1 day at 37°C using a Cytofluor 2350 fluorometric plate reader. As a positive control, all wells are exposed to 0.1% Triton X-100 at the end of the experiment[1].
References

[1]. Connop BP et al.Novel effects of FCCP [carbonyl cyanide p-(trifluoromethoxy)phenylhydrazone] on amyloid precursor protein processing. J Neurochem. 1999 Apr;72(4):1457-65.

[2]. Tanpradit N, et al. Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone (FCCP) pre-exposure ensures follicle integrity during in vitro culture of ovarian tissue but not during cryopreservation in the domestic cat model. J Assist Reprod Genet. 2016 Dec;33(12):1621-1631. Epub 2016 Sep 17.

Density 1.3±0.1 g/cm3
Boiling Point 293.3±50.0 °C at 760 mmHg
Melting Point 174-175ºC (dec.)(lit.)
Molecular Formula C10H5F3N4O
Molecular Weight 254.168
Flash Point 131.2±30.1 °C
Exact Mass 254.041550
PSA 81.20000
LogP 3.65
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.522
Storage condition 2-8°C
Water Solubility acetone: 20 mg/mL, clear, very deep greenish yellow
Symbol GHS06
GHS06
Signal Word Danger
Hazard Statements H301-H317-H413
Precautionary Statements P280-P301 + P310
Personal Protective Equipment Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes T: Toxic;Xi: Irritant;
Risk Phrases R25
Safety Phrases 36/37-45
RIDADR UN 2811 6
WGK Germany 3
RTECS FG5775000
Packaging Group II
Hazard Class 6.1(a)
HS Code 2928000090
Precursor  2

DownStream  0

HS Code 2928000090
Summary 2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%