793726-84-8

793726-84-8 structure

Name: BIBU1361
Chemical Name: N-(3-chloro-4-fluorophenyl)-6-[4-(diethylaminomethyl)piperidin-1-yl]pyrimido[5,4-d]pyrimidin-4-amine,dihydrochloride
CAS Number: 793726-84-8
Molecular Formula: C₂₂H₂₇ClFN₇
Molecular Weight: 443.95
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2016-07-22 07:26:06
Modify Date: 2024-01-27 21:58:59
BIBU1361 induces apoptosis and inhibits autophagy. BIBU1361 inhibits pro-survival pathways Akt/mTOR and gp130/JAK/STAT3, and decreased levels of pro-inflammatory cytokine IL-6[1].

Name	N-(3-chloro-4-fluorophenyl)-6-[4-(diethylaminomethyl)piperidin-1-yl]pyrimido[5,4-d]pyrimidin-4-amine,dihydrochloride
Synonyms	bibu 1361 dihydrochloride bibu 1361

Description	BIBU1361 induces apoptosis and inhibits autophagy. BIBU1361 inhibits pro-survival pathways Akt/mTOR and gp130/JAK/STAT3, and decreased levels of pro-inflammatory cytokine IL-6[1].
Related Catalog	Signaling Pathways >> PI3K/Akt/mTOR >> mTOR Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> Akt
References	[1]. Ruchi Ghildiyal, et, al. EGFR inhibitor BIBU induces apoptosis and defective autophagy in glioma cells. Mol Carcinog. 2013, 52,12.