2204230-40-8
2204230-40-8 structure
- Name: CM121
- Chemical Name: CM121
- CAS Number: 2204230-40-8
- Molecular Formula: C24H17FN4O3S
- Molecular Weight: 460.48
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Aldehyde Dehydrogenase (ALDH)
- Create Date: 2021-09-05 16:00:27
- Modify Date: 2024-01-14 12:16:47
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CM121 is an active site-directed reversible ALDH1A2 inhibitor (IC50=0.54 μM；Kd=1.1 μM) with a variety of hydrophobic interactions[1].
| Name | CM121 |
|---|
| Description | CM121 is an active site-directed reversible ALDH1A2 inhibitor (IC50=0.54 μM；Kd=1.1 μM) with a variety of hydrophobic interactions[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 0.54 μM (ALDH1A2), Kd: 1.1 μM (ALDH1A2)[1] |
| In Vitro | CM121 interacts with the main-chain amides of Cys320 and Thr321 and the side-chains of Thr321 and Asn187 via methylsulfonyl oxygen. CM121 establishes π-π stacking with the side chains of PHE188 and PHE314 through methylsulfonyl benzene and benzylonitrile rings[1]. |
| References |
| Molecular Formula | C24H17FN4O3S |
|---|---|
| Molecular Weight | 460.48 |