1158264-37-9

1158264-37-9 structure

Name: DC07090 dihydrochloride
Chemical Name: DC07090 dihydrochloride
CAS Number: 1158264-37-9
Molecular Formula: C₁₈H₁₆Cl₂N₄O
Molecular Weight: 375.25
Catalog: Research Areas Infection
Create Date: 2021-09-09 13:23:54
Modify Date: 2024-04-06 17:59:12
DC07090 dihydrochloride is a low toxicity, potent, reversible and competitive non-peptidyl human enterovirus 71 3C protease inhibitor with an IC50 and a Ki value for 21.72 μM and 23.29 μM. DC07090 dihydrochloride could also inhibit coxsackievirus A16 (CVA16) replication with an EC50 value of 27.76 μM[1].

Name	DC07090 dihydrochloride

Description	DC07090 dihydrochloride is a low toxicity, potent, reversible and competitive non-peptidyl human enterovirus 71 3C protease inhibitor with an IC50 and a Ki value for 21.72 μM and 23.29 μM. DC07090 dihydrochloride could also inhibit coxsackievirus A16 (CVA16) replication with an EC50 value of 27.76 μM[1].
Related Catalog	Research Areas >> Infection
Target	IC50: 21.72 μM (EV71 3C protease)[1]. Ki: 23.29 μM (EV71 3C protease)[1]. EC50: 27.76 μM (coxsackievirus A16)[1]
In Vitro	DC07090 dihydrochloride forms stable hydrogen-bonding interactions with the main chains of S128, G145, G164 and hydrophobic interactions with F25, L125, L127 and F170. DC07090 dihydrochloride (0.01~10 μM) shows micromolar potency against EV71 3Cpro. DC07090 dihydrochloride exhibits a highly inhibitory potency on EV71 replication with an EC50 value of 22.09 μM. DC07090 dihydrochloride inhibits CVA16 with an EC50 value of 27.76 μM[1].
References	[1]. Ma GH, et al. Identification and biochemical characterization of DC07090 as a novel potent small molecule inhibitor against human enterovirus 71 3C protease by structure-based virtual screening. Eur J Med Chem. 2016 Nov 29;124:981-991.

Molecular Formula	C₁₈H₁₆Cl₂N₄O
Molecular Weight	375.25