2159137-02-5

2159137-02-5 structure

Name: GSK097
Chemical Name: GSK097
CAS Number: 2159137-02-5
Molecular Formula: C₁₉H₂₁N₃O₃
Molecular Weight: 339.39
Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
Create Date: 2021-09-12 15:31:52
Modify Date: 2024-01-21 12:28:35
GSK097 is a potent and selective Inhibitor of the second bromodomain (BD2) of the bromodomain and extra-terminal domain (BET) proteins. GSK097 displays 2000-fold selective for BD2 over BD1 (BRD4 data) with >1 mg/mL solubility in FaSSIF media[1].

Name	GSK097

Description	GSK097 is a potent and selective Inhibitor of the second bromodomain (BD2) of the bromodomain and extra-terminal domain (BET) proteins. GSK097 displays 2000-fold selective for BD2 over BD1 (BRD4 data) with >1 mg/mL solubility in FaSSIF media[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain
In Vitro	GSK097 displays pIC50s 7.4, 8.0, 7.6, and 7.9 for BRD2 BD2, BRD3 BD2, BRD4 BD2 and BRDT BD2, respectively[1].
References	[1]. Harrison LA, et al. Identification of a Series of N-Methylpyridine-2-carboxamides as Potent and Selective Inhibitors of the Second Bromodomain (BD2) of the Bromo and Extra Terminal Domain (BET) Proteins [published online ahead of print, 2021 Jul 7]. J Med Chem. 2021;10.1021/acs.jmedchem.0c02155.

Molecular Formula	C₁₉H₂₁N₃O₃
Molecular Weight	339.39