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105250-85-9

105250-85-9 structure
105250-85-9 structure
  • Name: Osteogenic Growth Peptide (10-14) trifluoroacetate salt
  • Chemical Name: Osteogenic Growth Peptide (10-14)
  • CAS Number: 105250-85-9
  • Molecular Formula: C24H29N5O7
  • Molecular Weight: 499.51600
  • Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK Src
  • Create Date: 2017-01-13 14:52:15
  • Modify Date: 2024-01-02 19:35:01
  • Osteogenic Growth Peptide (10-14) (OGP(10-14)), the C-terminal truncated pentapeptide of osteogenic growth peptide (OGP), retains the full OGP-like activity. Osteogenic Growth Peptide (10-14) is responsible for the binding to the OGP receptor and activates an intracellular Gi-protein-MAP kinase signaling pathway. Osteogenic Growth Peptide (10-14) is a potent mitogen and stimulator of osteogenesis and hematopoiesis. Osteogenic Growth Peptide (10-14) acts as a Src inhibitor[1][2][3][4].
Name Osteogenic Growth Peptide (10-14)
Synonyms Tyr-Gly-Phe-Gly-gly
Glycine,N-(N-(N-(N-L-tyrosylglycyl)-L-phenylalanyl)glycyl)
H-TYR-GLY-PHE-GLY-GLY-OH
historphin
Tyrosyl-glycyl-phenylalanyl-glycyl-glycine
OGP (10-14)
Description Osteogenic Growth Peptide (10-14) (OGP(10-14)), the C-terminal truncated pentapeptide of osteogenic growth peptide (OGP), retains the full OGP-like activity. Osteogenic Growth Peptide (10-14) is responsible for the binding to the OGP receptor and activates an intracellular Gi-protein-MAP kinase signaling pathway. Osteogenic Growth Peptide (10-14) is a potent mitogen and stimulator of osteogenesis and hematopoiesis. Osteogenic Growth Peptide (10-14) acts as a Src inhibitor[1][2][3][4].
Related Catalog
In Vitro Osteogenic Growth Peptide (10-14) (OGP(10-14)) induces proliferation and differentiation in fibroblast and osteoblast cell lines[3]. Osteogenic Growth Peptide (10-14) induces TPO-primed M07-e cells differentiation through RhoA/TGFβ1/SFKs signalling pathway. In particular Historphin acts as a Src inhibitor, showing the same effects of PP2[4].
In Vivo Osteogenic Growth Peptide (10-14) (OGP(10-14)) increases bone formation and trabecular bone density and stimulates fracture healing when administered to mice and rats[1].
References

[1]. Chen YC, et al. Bioactive pseudopeptidic analogues and cyclostereoisomers of osteogenic growth peptide C-terminal pentapeptide, OGP(10-14). J Med Chem. 2002;45(8):1624-1632.

[2]. Chen Z, et al. Regulation of endochondral ossification by osteogenic growth peptide C-terminal pentapeptide [OGP(10-14)]. Protein Pept Lett. 2009;16(9):1074-1080.

[3]. Fazzi R, et al. Bone and bone-marrow interactions: haematological activity of osteoblastic growth peptide (OGP)-derived carboxy-terminal pentapeptide. Mobilizing properties on white blood cells and peripheral blood stem cells in mice. Leuk Res. 2002;26(1):19-27.

[4]. Battolla B, et al. The small peptide OGP(10-14) reduces proliferation and induces differentiation of TPO-primed M07-e cells through RhoA/TGFbeta1/SFK pathway. Med Sci Monit. 2011;17(1):SC1-SC5.
Density 1.352g/cm3
Boiling Point 1028ºC at 760mmHg
Molecular Formula C24H29N5O7
Molecular Weight 499.51600
Flash Point 575.5ºC
Exact Mass 499.20700
PSA 199.95000
LogP 0.68660
Vapour Pressure 0mmHg at 25°C
Index of Refraction 1.609

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title: CAS No. 105250-85-9 | Chemsrc address: https://www.chemsrc.com/en/baike/168135.html

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