Shanghai Nianxing Industrial Co., Ltd
China
Product Name: LUF5771
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang

DC Chemicals Limited
China
Product Name: LUF5771
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Cao

1141802-49-4

1141802-49-4 structure

1141802-49-4 structure

Name: LUF5771
Chemical Name: LUF5771
CAS Number: 1141802-49-4
Molecular Formula: C₂₄H₂₃NO₂
Molecular Weight: 357.44
Catalog: Research Areas Endocrinology
Create Date: 2021-09-05 07:14:26
Modify Date: 2024-01-10 11:30:21
LUF5771 is a potent allosteric recombinant luteinizing hormone (recLH) and Org 43553 inhibitor. LUF5771 is able to partially activate the LH receptor with low efficacy[1].

Name	LUF5771

Description	LUF5771 is a potent allosteric recombinant luteinizing hormone (recLH) and Org 43553 inhibitor. LUF5771 is able to partially activate the LH receptor with low efficacy[1].
Related Catalog	Research Areas >> Endocrinology Signaling Pathways >> Others >> Others
Target	recLH and Org 43553[1]
In Vitro	LUF5771 (1 µM or 10 µM) allosteric inhibition is concentration-dependent. LUF5771 significantly increases radioligand dissociation. LUF5771 probably binds to the seven transmembrane domain like Org 43553 does. LUF5771 (10 µM) alone is able to partially activate the LH receptor by 31±4%[1].
References	[1]. Laura H. Heitman, et al. Substituted Terphenyl Compounds as the First Class of Low Molecular Weight Allosteric Inhibitors of the Luteinizing Hormone Receptor. Journal of Medicinal Chemistry 2009 52 (7), 2036-2042

Molecular Formula	C₂₄H₂₃NO₂
Molecular Weight	357.44