2459963-17-6

2459963-17-6 structure

Name: 6-(4-(4-Methylthiazol-2-yl)-1H-imidazol-5-yl)benzo[d]thiazole hydrochloride
Chemical Name: 6-(4-(4-Methylthiazol-2-yl)-1H-imidazol-5-yl)benzo[d]thiazole hydrochloride
CAS Number: 2459963-17-6
Molecular Formula: C₁₄H₁₁ClN₄S₂
Molecular Weight: 334.847
Catalog: Research Areas Endocrinology
Create Date: 2021-11-17 14:28:41
Modify Date: 2024-04-11 12:37:18
TP0427736 hydrochloride is a potent inhibitor of ALK5 kinase activity with an IC50 of 2.72 nM and this effect is 300-fold higher than the inhibitory effect on ALK3 (IC50=836 nM). TP0427736 hydrochloride also inhibits Smad2/3 phosphorylation in A549 cells induced by TGF-β1 with an IC50 value of 8.68 nM. TP0427736 hydrochloride can be used for the research of androgenic alopecia (AGA)[1].

Name	6-(4-(4-Methylthiazol-2-yl)-1H-imidazol-5-yl)benzo[d]thiazole hydrochloride
Synonyms	Benzothiazole, 6-[4-(4-methyl-2-thiazolyl)-1H-imidazol-5-yl]-, hydrochloride (1:1) 6-[4-(4-Methyl-1,3-thiazol-2-yl)-1H-imidazol-5-yl]-1,3-benzothiazole hydrochloride (1:1) MFCD32633583

Description	TP0427736 hydrochloride is a potent inhibitor of ALK5 kinase activity with an IC50 of 2.72 nM and this effect is 300-fold higher than the inhibitory effect on ALK3 (IC50=836 nM). TP0427736 hydrochloride also inhibits Smad2/3 phosphorylation in A549 cells induced by TGF-β1 with an IC50 value of 8.68 nM. TP0427736 hydrochloride can be used for the research of androgenic alopecia (AGA)[1].
Related Catalog	Research Areas >> Endocrinology
References	[1]. Takumi Naruse, et al. Novel ALK5 inhibitor TP0427736 reduces TGF-β induced growth inhibition in human outer root sheath cells and elongates anagen phase in mouse hair follicles. Pharmacol Rep. 2017 May;69(3):485-491.