Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 2-(4-isobutylphenyl)-N-(methylsulfonyl)propanamide
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Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang

957407-64-6

957407-64-6 structure

Name: Reparixin Racemate
Chemical Name: n-[2-(4-isobutyl-phenyl)-propionyl]-methane sulfonamide
CAS Number: 957407-64-6
Molecular Formula: C₁₄H₂₁NO₃S
Molecular Weight: 283.39
Catalog: Research Areas Cancer
Create Date: 2021-11-15 19:52:18
Modify Date: 2024-02-04 16:08:14
(Rac)-Reparixin is the inactive isomer of Reparixin (HY-15251), and can be used as an experimental control. Reparixin is a non-competitive allosteric inhibitor of the chemokine receptors CXCR1 and CXCR2 activation with IC50s of 1 and 100 nM, respectively.

Name	n-[2-(4-isobutyl-phenyl)-propionyl]-methane sulfonamide
Synonyms	MFCD16621248 MFCD18633292 Benzeneacetamide, α-methyl-4-(2-methylpropyl)-N-(methylsulfonyl)- reparixin 2-(4-Isobutylphenyl)-N-(methylsulfonyl)propanamide

Description	(Rac)-Reparixin is the inactive isomer of Reparixin (HY-15251), and can be used as an experimental control. Reparixin is a non-competitive allosteric inhibitor of the chemokine receptors CXCR1 and CXCR2 activation with IC50s of 1 and 100 nM, respectively.
Related Catalog	Research Areas >> Cancer Research Areas >> Endocrinology Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
References	[1]. Sousa LF, et al. Blockade of CXCR1/2 chemokine receptors protects against brain damage in ischemic stroke in mice. Clinics (Sao Paulo). 2013;68(3):391-4. [2]. Bertini R, et al. Noncompetitive allosteric inhibitors of the inflammatory chemokine receptors CXCR1 and CXCR2: prevention of reperfusion injury. Proc Natl Acad Sci U S A. 2004 Aug 10;101(32):11791-6. [3]. Krishnamurthy A, et al. Identification of a novel chemokine-dependent molecular mechanism underlying rheumatoid arthritis-associated autoantibody-mediated bone loss. Ann Rheum Dis. 2016 Apr;75(4):721-9. [4]. Crespo J, et al. Human Naive T Cells Express Functional CXCL8 and Promote Tumorigenesis. J Immunol. 2018 Jul 15;201(2):814-820. [5]. Moriconi A, et al. Design of noncompetitive interleukin-8 inhibitors acting on CXCR1 and CXCR2. J Med Chem. 2007 Aug 23;50(17):3984-4002. [6]. Bertini R, et al. Receptor binding mode and pharmacological characterization of a potent and selective dual CXCR1/CXCR2non-competitive allosteric inhibitor. Br J Pharmacol. 2012 Jan;165(2):436-54. [7]. Kim HY, et al. Reparixin, an inhibitor of CXCR1 and CXCR2 receptor activation, attenuates blood pressure and hypertension-related mediators expression in spontaneously hypertensive rats. Biol Pharm Bull. 2011;34(1):120-7.

Density	1.1±0.1 g/cm3
Molecular Formula	C₁₄H₂₁NO₃S
Molecular Weight	283.39
Exact Mass	283.124207
LogP	2.66
Index of Refraction	1.525
Storage condition	2-8°C

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