2135640-93-4
2135640-93-4 structure
- Name: (+)-JNJ-A07
- Chemical Name: (+)-JNJ-A07
- CAS Number: 2135640-93-4
- Molecular Formula: C28H26ClF3N2O6
- Molecular Weight: 578.96
- Catalog: Research Areas Infection
- Create Date: 2022-04-01 23:52:51
- Modify Date: 2024-04-08 15:36:15
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(+)-JNJ-A07 is a highly potent, orally active pan-serotype dengue virus inhibitor targeting the NS3-NS4B interaction. (+)-JNJ-A07 exerts nanomolar to picomolar activity against a panel of 21 clinical isolates. (+)-JNJ-A07 has a favourable pharmacokinetic profile that results in outstanding efficacy against dengue virus infection in mouse infection models[1].
| Name | (+)-JNJ-A07 |
|---|
| Description | (+)-JNJ-A07 is a highly potent, orally active pan-serotype dengue virus inhibitor targeting the NS3-NS4B interaction. (+)-JNJ-A07 exerts nanomolar to picomolar activity against a panel of 21 clinical isolates. (+)-JNJ-A07 has a favourable pharmacokinetic profile that results in outstanding efficacy against dengue virus infection in mouse infection models[1]. |
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| Related Catalog | |
| In Vitro | (+)-JNJ-A07 has a high barrier to resistance and prevents the formation of the viral replication complex by blocking the interaction between two viral proteins (NS3 and NS4B)[1]. |
| References |
| Molecular Formula | C28H26ClF3N2O6 |
|---|---|
| Molecular Weight | 578.96 |