1256390-53-0

1256390-53-0 structure

Name: GSK2236805
Chemical Name: GSK-2336805
CAS Number: 1256390-53-0
Molecular Formula: C₄₂H₅₂N₈O₈
Molecular Weight: 796.91
Catalog: Signaling Pathways Anti-infection HCV
Create Date: 2022-03-28 19:01:09
Modify Date: 2024-01-02 19:03:36
GSK2236805 is a potent hepatitis C virus inhibitor with pEC50 values of 10.4, 11.1 for HCV genotype 1a (gt1a) and gt1b, respectively[1].

Name	GSK-2336805
Synonyms	Carbamic acid, N-[(1S)-1-[[(2S)-2-[5-[4'-[2-[(8S)-7-[(2S)-2-[(methoxycarbonyl)amino]-3-methyl-1-oxobutyl]-1,4-dioxa-7-azaspiro[4.4]non-8-yl]-1H-imidazol-5-yl][1,1'-biphenyl]-4-yl]-1H-imidazol-2-yl]-1-pyrrolidinyl]carbonyl]-2-methylpropyl]-, methyl ester MFCD28963895 Methyl [(2S)-1-{(8S)-8-[4-(4'-{2-[(2S)-1-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}-2-pyrrolidinyl]-1H-imidazol-4-yl}-4-biphenylyl)-1H-imidazol-2-yl]-1,4-dioxa-7-azaspiro[4.4]non-7-yl}-3-methyl-1-oxo-2-butanyl]carbamate GSK-2336805

Description	GSK2236805 is a potent hepatitis C virus inhibitor with pEC50 values of 10.4, 11.1 for HCV genotype 1a (gt1a) and gt1b, respectively[1].
Related Catalog	Signaling Pathways >> Anti-infection >> HCV Research Areas >> Infection
Target	pEC50: 10.4 (gt1a); 11.1 µM (gt1b)[1]
References	[1]. Kazmierski WM, et al. Novel spiroketal pyrrolidine GSK2336805 potently inhibits key hepatitis C virus genotype 1b mutants: from lead to clinical compound. J Med Chem. 2014 Mar 13;57(5):2058-73.