2227429-65-2

2227429-65-2 structure

Name: ADH-6
Chemical Name: ADH-6
CAS Number: 2227429-65-2
Molecular Formula: C₂₉H₃₆N₈O₉
Molecular Weight: 640.64
Create Date: 2022-05-23 12:30:03
Modify Date: 2024-01-02 16:23:19
ADH-6 is a tripyridylamide compound. ADH-6 abrogates self-assembly of the aggregation-nucleating subdomain of mutant p53 DBD. ADH-6 targets and dissociates mutant p53 aggregates in human cancer cells, which restores p53's transcriptional activity, leading to cell cycle arrest and apoptosis. ADH-6 has the potential for the research of cancer diseases[1].

Name	ADH-6

Description	ADH-6 is a tripyridylamide compound. ADH-6 abrogates self-assembly of the aggregation-nucleating subdomain of mutant p53 DBD. ADH-6 targets and dissociates mutant p53 aggregates in human cancer cells, which restores p53's transcriptional activity, leading to cell cycle arrest and apoptosis. ADH-6 has the potential for the research of cancer diseases[1].
Related Catalog	Research Areas >> Cancer
References	[1]. Palanikumar L, et al. Protein mimetic amyloid inhibitor potently abrogates cancer-associated mutant p53 aggregation and restores tumor suppressor function. Nat Commun. 2021;12(1):3962.

Molecular Formula	C₂₉H₃₆N₈O₉
Molecular Weight	640.64