2684258-54-4
2684258-54-4 structure
- Name: RET-IN-13
- Chemical Name: RET-IN-13
- CAS Number: 2684258-54-4
- Molecular Formula: C32H33F4N5O3
- Molecular Weight: 611.63
- Create Date: 2022-06-01 12:01:06
- Modify Date: 2024-02-25 17:52:39
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RET-IN-13 (compound 1), a quinoline compound, is a potent RET inhibitor with IC50s of 0.5 nM, 0.9 nM for RET (WT) and RET (V804M), respectively. RET-IN-13 has the potential for tumors or intestinal diseases related to abnormal activation of RET research[1].
| Name | RET-IN-13 |
|---|
| Description | RET-IN-13 (compound 1), a quinoline compound, is a potent RET inhibitor with IC50s of 0.5 nM, 0.9 nM for RET (WT) and RET (V804M), respectively. RET-IN-13 has the potential for tumors or intestinal diseases related to abnormal activation of RET research[1]. |
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| Related Catalog | |
| In Vitro | RET-IN-13 has low inhibition on CYP1A2 (IC50>50 μM), CYP2C9 (IC50=12.5 μM), CYP2C19 (IC50=16.9 μM), CYP2D6 (IC50=18.8 μM) and CYP3A4 (IC50>50 μM)[1]. |
| In Vivo | RET-IN-13 (compound 1; 0.5 mpk; iv) has a T1/2 of 6.93 hours, a CL of 2.68 mL/min·kg, and a Vdss of 1.52 L/kg for male mice[1]. RET-IN-13 (2.5 mpk; po) has a T1/2 of 5.16 hours, Cmax of 0.958 μM and an AUC of 12477 μM·hr for male mice[1]. |
| References |
[1]. Jiansong Wang, et al. Quinoline compounds. WO2021164742A1. |
| Molecular Formula | C32H33F4N5O3 |
|---|---|
| Molecular Weight | 611.63 |