1895051-79-2
1895051-79-2 structure
- Name: MT16-205
- Chemical Name: MT16-205
- CAS Number: 1895051-79-2
- Molecular Formula: C17H14N4Os
- Molecular Weight: 322.386
- Create Date: 2022-07-07 03:14:29
- Modify Date: 2024-09-30 13:24:13
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MT16-205 (MT 16-205) is a potent, selective, covalent UCHL1 inhibitor with IC50 of 600 nM, no inhibition agianst UCHL3 (IC50>10 uM).MT16-205 inhibited both UCHL1 and the structurally unrelated DUB USP30 with similar potency.MT16-205 displayed cell proliferation cytotoxicity in human embryonic kidney cells (HEK293) with IC50 of 350 nM, MT16-205 effectively engaged UCHL1 in cells with IC50 of 830 nM.
| Name | MT16-205 |
|---|
| Description | MT16-205 (MT 16-205) is a potent, selective, covalent UCHL1 inhibitor with IC50 of 600 nM, no inhibition agianst UCHL3 (IC50>10 uM).MT16-205 inhibited both UCHL1 and the structurally unrelated DUB USP30 with similar potency.MT16-205 displayed cell proliferation cytotoxicity in human embryonic kidney cells (HEK293) with IC50 of 350 nM, MT16-205 effectively engaged UCHL1 in cells with IC50 of 830 nM. |
|---|---|
| References | 1. Nattawadee Panyain, et al. RSC Med Chem. 2021 Aug 16;12(11):1935-1943. |
| Molecular Formula | C17H14N4Os |
|---|---|
| Molecular Weight | 322.386 |