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  • DC Chemicals Limited
  • China
  • Product Name: RTICBM-74
  • Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

2130881-32-0

2130881-32-0 structure
2130881-32-0 structure
  • Name: RTICBM-74
  • Chemical Name: RTICBM-74
  • CAS Number: 2130881-32-0
  • Molecular Formula: C19H14ClFN2O
  • Molecular Weight: 340.782
  • Create Date: 2022-07-01 17:56:31
  • Modify Date: 2024-04-06 20:26:08
  • RTICBM-74 is a potent, selective, brain-penetrant CB1 negative allosteric modulator (NAM) with IC50 of 23 nM in Ca2+ assays.RTICBM-74 displays excellent half-life and low clearance against rat liver microsomes and hepatocytes, and excellent brain penetrance in rats.RTICBM-74 specifically reduces alcohol intake across a range of doses in male or female Wistar or Long-Evans rats, reduces alcohol intake and does not affect locomotion or sucrose self-administration.

Name RTICBM-74
Description RTICBM-74 is a potent, selective, brain-penetrant CB1 negative allosteric modulator (NAM) with IC50 of 23 nM in Ca2+ assays.RTICBM-74 displays excellent half-life and low clearance against rat liver microsomes and hepatocytes, and excellent brain penetrance in rats.RTICBM-74 specifically reduces alcohol intake across a range of doses in male or female Wistar or Long-Evans rats, reduces alcohol intake and does not affect locomotion or sucrose self-administration.
References 1. Nguyen T, et al. J Med Chem. 2017 Sep 14;60(17):7410-7424. 2. Lovelock DF, et al. J Pharmacol Exp Ther. 2022 Mar;380(3):153-161.
Molecular Formula C19H14ClFN2O
Molecular Weight 340.782