2206744-61-6
2206744-61-6 structure
- Name: SKI-73
- Chemical Name: SKI-73
- CAS Number: 2206744-61-6
- Molecular Formula: C46H58N8O8
- Molecular Weight: 851.018
- Create Date: 2022-07-02 10:11:32
- Modify Date: 2024-09-10 08:36:30
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SKI-73 is a CARM1 chemical probe with pro-drug properties, can readily penetrate cell membranes and then be processed into two active CARM1 inhibitors.SKI-73 (10 uM) fully suppresses the methylation of BAF155 Arg1064 in MCF-7 cells.SKI-73 inhibits in vitro invasion but not proliferation of breast cancer cells ( MDA-MB-231 cell, EC50=1.3 uM).SKI-73 recapitulates the anti-invasion effect of the genetic perturbation of CARM1.Either CARM1 knockout or CARM1 inhibition with SKI-73 alters the epigenetic plasticity in a proliferation-independent manner by replacing the most invasion-prone subpopulation with the non-invasive subpopulation(s) to suppress the invasive phenotype.
| Name | SKI-73 |
|---|
| Description | SKI-73 is a CARM1 chemical probe with pro-drug properties, can readily penetrate cell membranes and then be processed into two active CARM1 inhibitors.SKI-73 (10 uM) fully suppresses the methylation of BAF155 Arg1064 in MCF-7 cells.SKI-73 inhibits in vitro invasion but not proliferation of breast cancer cells ( MDA-MB-231 cell, EC50=1.3 uM).SKI-73 recapitulates the anti-invasion effect of the genetic perturbation of CARM1.Either CARM1 knockout or CARM1 inhibition with SKI-73 alters the epigenetic plasticity in a proliferation-independent manner by replacing the most invasion-prone subpopulation with the non-invasive subpopulation(s) to suppress the invasive phenotype. |
|---|---|
| References | 1. Xiao-Chuan Cai, et al. Elife. 2019 Oct 28;8:e47110. |
| Molecular Formula | C46H58N8O8 |
|---|---|
| Molecular Weight | 851.018 |