2540502-26-7
2540502-26-7 structure
- Name: KNa1.1 inhibitor 31
- Chemical Name: KNa1.1 inhibitor 31
- CAS Number: 2540502-26-7
- Molecular Formula: C16H12F6N6O2
- Molecular Weight: 434.302
- Create Date: 2022-07-06 11:40:11
- Modify Date: 2024-02-04 15:40:47
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KNa1.1 inhibitor 31 is a potent, selective, orally available inhibitor of sodium-activated potassium channel KNa1.1 (Slack, Slo2.2) with IC50 of 40 nM (hKNa1.1 WT).KNa1.1 inhibitor 31 reduced seizures and interictal spikes in a mouse model of KCNT1 GoF.
| Name | KNa1.1 inhibitor 31 |
|---|
| Description | KNa1.1 inhibitor 31 is a potent, selective, orally available inhibitor of sodium-activated potassium channel KNa1.1 (Slack, Slo2.2) with IC50 of 40 nM (hKNa1.1 WT).KNa1.1 inhibitor 31 reduced seizures and interictal spikes in a mouse model of KCNT1 GoF. |
|---|---|
| References | 1. Andrew M Griffin, et al. ACS Med Chem Lett. 2021 Mar 9;12(4):593-602. |
| Molecular Formula | C16H12F6N6O2 |
|---|---|
| Molecular Weight | 434.302 |