2566480-62-2
2566480-62-2 structure
- Name: UC-764864
- Chemical Name: UC-764864
- CAS Number: 2566480-62-2
- Molecular Formula: C19H18N2Os
- Molecular Weight: 322.426
- Create Date: 2022-07-02 19:27:59
- Modify Date: 2024-04-03 10:26:03
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UC-764864 (UC764864) is a small-molecule inhibitor that targeted ubiquitin-conjugating enzyme UBE2N active site.UC-764864 blocks ubiquitination of innate immune- and inflammatory-related substrates in human AML cell lines.Inhibition of UBE2N function disrupted oncogenic immune signaling by promoting cell death of leukemic HSPCs while sparing normal HSPCs in vitro.
| Name | UC-764864 |
|---|
| Description | UC-764864 (UC764864) is a small-molecule inhibitor that targeted ubiquitin-conjugating enzyme UBE2N active site.UC-764864 blocks ubiquitination of innate immune- and inflammatory-related substrates in human AML cell lines.Inhibition of UBE2N function disrupted oncogenic immune signaling by promoting cell death of leukemic HSPCs while sparing normal HSPCs in vitro. |
|---|---|
| References | 1. Laura Barreyro, et al. Sci Transl Med. 2022 Mar 9;14(635):eabb7695. |
| Molecular Formula | C19H18N2Os |
|---|---|
| Molecular Weight | 322.426 |