2758364-02-0
2758364-02-0 structure
- Name: CAM833
- Chemical Name: CAM833
- CAS Number: 2758364-02-0
- Molecular Formula: C27H29FN4O5
- Molecular Weight: 508.55
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2022-07-11 12:52:17
- Modify Date: 2024-01-03 19:07:33
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CAM833 (CAM-833) is a potent, specific chemical inhibitor of the RAD51-BRCA2 interaction and RAD51 oligomerization with Kd of 366 nM;CAM833 inhibited RAD51 foci formation 6 h after exposure to 3 Gy IR, in a concentration-dependent manner with an IC50 of 6 uM, causeed a concentration-dependent decrease in RAD51 foci accompanied by increased DNA damage in A549 cells.CAM833 inhibted RAD51 molecular clustering at DNA damage sites visualized by SMLM, suppressed homologous recombination and potentiated cell-cycle arrest.CAM833 potentiated the growth suppressive effect of PARP1 inhibition in BRCA2 wild-type cells, as well as dose-dependent growth inhibition when combined with ionizing radiation.
| Name | CAM833 |
|---|
| Description | CAM833 (CAM-833) is a potent, specific chemical inhibitor of the RAD51-BRCA2 interaction and RAD51 oligomerization with Kd of 366 nM;CAM833 inhibited RAD51 foci formation 6 h after exposure to 3 Gy IR, in a concentration-dependent manner with an IC50 of 6 uM, causeed a concentration-dependent decrease in RAD51 foci accompanied by increased DNA damage in A549 cells.CAM833 inhibted RAD51 molecular clustering at DNA damage sites visualized by SMLM, suppressed homologous recombination and potentiated cell-cycle arrest.CAM833 potentiated the growth suppressive effect of PARP1 inhibition in BRCA2 wild-type cells, as well as dose-dependent growth inhibition when combined with ionizing radiation. |
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| References | 1. Duncan E Scott, et al. Cell Chem Biol. 2021 Jun 17;28(6):835-847.e5. |
| Molecular Formula | C27H29FN4O5 |
|---|---|
| Molecular Weight | 508.55 |