852863-80-0
852863-80-0 structure
- Name: Myomed-946
- Chemical Name: Myomed-946
- CAS Number: 852863-80-0
- Molecular Formula: C26H22N2O8
- Molecular Weight: 490.468
- Create Date: 2022-08-23 19:55:27
- Modify Date: 2024-02-07 13:57:38
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MyoMed-946 is a small moelcule that inhibits MuRF1 (TRIM63) activity and MuRF1/MuRF2 expression;MyoMed-946 inhibits MuRF1 expression/activity in vivo and is able to attenuate skeletal muscle atrophy and dysfunction in mice treated with monocrotaline to induce right ventricular hypertrophy and subsequent cardiac cachexia.MyoMed-946 attenuates skeletal muscle strength loss in mouse model for type 2 diabetes mellitus (T2DM), with no significant effects on serum glucose.MyoMed-946 attenuates induction of MuRF1 in tumor stressed muscles.MyoMed-946 also rescues citrate synthase and complex-1 activities in tumor-stressed muscles.MuRF1 (muscle-specific RING finger protein-1) is a muscle-specific ubiquitin ligase that regulates muscle catabolism during chronic wasting states, both MuRF1 and MuRF2 participate in glucose and, also, in lipid regulation.
| Name | Myomed-946 |
|---|
| Description | MyoMed-946 is a small moelcule that inhibits MuRF1 (TRIM63) activity and MuRF1/MuRF2 expression;MyoMed-946 inhibits MuRF1 expression/activity in vivo and is able to attenuate skeletal muscle atrophy and dysfunction in mice treated with monocrotaline to induce right ventricular hypertrophy and subsequent cardiac cachexia.MyoMed-946 attenuates skeletal muscle strength loss in mouse model for type 2 diabetes mellitus (T2DM), with no significant effects on serum glucose.MyoMed-946 attenuates induction of MuRF1 in tumor stressed muscles.MyoMed-946 also rescues citrate synthase and complex-1 activities in tumor-stressed muscles.MuRF1 (muscle-specific RING finger protein-1) is a muscle-specific ubiquitin ligase that regulates muscle catabolism during chronic wasting states, both MuRF1 and MuRF2 participate in glucose and, also, in lipid regulation. |
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| References | 1. Eva Zaccariotto, et al. J Cachexia Sarcopenia Muscle. 2022 Mar 17. 2. Adams V, et al. Cells. 2020 Oct 11;9(10):2272. 3. Labeit S, et al. Int J Mol Sci. 2021 Feb 23;22(4):2225. 4. Bowen TS, et al. J Cachexia Sarcopenia Muscle. 2017 Dec;8(6):939-953. |
| Molecular Formula | C26H22N2O8 |
|---|---|
| Molecular Weight | 490.468 |