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922067-76-3

922067-76-3 structure
922067-76-3 structure
  • Name: UHRF1 PHD inhibitor MLD4
  • Chemical Name: UHRF1 PHD inhibitor MLD4
  • CAS Number: 922067-76-3
  • Molecular Formula: C22H32N4O4
  • Molecular Weight: 416.522
  • Create Date: 2022-07-01 14:17:27
  • Modify Date: 2024-02-04 18:54:02
  • UHRF1 PHD inhibitor MLD4 is a specific compound that selectively inhibits the UHRF1-histone interaction (IC50=12.4 uM), targets the PHD finger of UHRF1, specifically disrupting histone H3 arginine 2 interactions with the PHD finger.UHRF1 PHD inhibitor MLD4 inhibited binding between H3K9me3(FAM) and UHRF1 with IC50 of 24-26 uM, displace UHRF1-histone H3 binding in cells.

Name UHRF1 PHD inhibitor MLD4
Description UHRF1 PHD inhibitor MLD4 is a specific compound that selectively inhibits the UHRF1-histone interaction (IC50=12.4 uM), targets the PHD finger of UHRF1, specifically disrupting histone H3 arginine 2 interactions with the PHD finger.UHRF1 PHD inhibitor MLD4 inhibited binding between H3K9me3(FAM) and UHRF1 with IC50 of 24-26 uM, displace UHRF1-histone H3 binding in cells.
References 1. Wallace H Liu, et al. Biochemistry. 2022 Feb 10.
Molecular Formula C22H32N4O4
Molecular Weight 416.522