2365230-48-2

2365230-48-2 structure

Name: SY-5102
Chemical Name: SY-5102
CAS Number: 2365230-48-2
Molecular Formula: C₂₂H₂₂F₃N₇O
Molecular Weight: 457.45
Create Date: 2022-08-01 22:48:36
Modify Date: 2024-01-11 18:03:50
SY-5102 (SY5102) is a highly potent, selective, noncovalent, orally available CDK7 inhibitor with SPR Kd of 0.03 nM (binding to CDK7/Cyclin H).SY-5102 (SY5102) displays highly selectivity against CDK2, CDK9, and CDK12 (all IC50>75 nM).SY-5102 potently inhibits HCC70 cell proliferation with EC50 of 9 nM.SY-5102 showed dose-dependent tumor growth inhibition including tumor regression at 4 mg/kg po (dosed twice daily) in an HCC70 cell line derived xenograft mouse model.

Name	SY-5102

Description	SY-5102 (SY5102) is a highly potent, selective, noncovalent, orally available CDK7 inhibitor with SPR Kd of 0.03 nM (binding to CDK7/Cyclin H).SY-5102 (SY5102) displays highly selectivity against CDK2, CDK9, and CDK12 (all IC50>75 nM).SY-5102 potently inhibits HCC70 cell proliferation with EC50 of 9 nM.SY-5102 showed dose-dependent tumor growth inhibition including tumor regression at 4 mg/kg po (dosed twice daily) in an HCC70 cell line derived xenograft mouse model.
References	1. Jason J Marineau, et al. J Med Chem. 2022 Jan 27;65(2):1458-1480.

Molecular Formula	C₂₂H₂₂F₃N₇O
Molecular Weight	457.45