2436472-47-6
2436472-47-6 structure
- Name: ARN-75039
- Chemical Name: ARN-75039
- CAS Number: 2436472-47-6
- Molecular Formula: C27H30N2O2
- Molecular Weight: 414.549
- Create Date: 2022-06-27 12:46:31
- Modify Date: 2024-01-12 13:30:56
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ARN-75039 (ARN75039) is a potent, small molecule fusion inhibitor of arenavirus, inhibits pseudotyped entry of pGTOV and pCHAPV with EC50 of 0.13 and 4.3 nM, respectively.ARN-75039 demonstrated sub-nanomolar EC50 activity against pTCRV that further translated to native wild-and NWAs, including LASV, JUNV and MACV, in pseudotyped virus assays and against native replicative LASV and JUNV.ARN-75039 also potently inhibits mutant T434I pTCRV variant with EC50 of 29 nM.ARN-75039 dramatically improved survival outcome and potently inhibited TCRV replication in serum and various tissues at doses of 10 and 35 mg/kg, provided highly significant post-exposure protection in mice against TCRV infection.
| Name | ARN-75039 |
|---|
| Description | ARN-75039 (ARN75039) is a potent, small molecule fusion inhibitor of arenavirus, inhibits pseudotyped entry of pGTOV and pCHAPV with EC50 of 0.13 and 4.3 nM, respectively.ARN-75039 demonstrated sub-nanomolar EC50 activity against pTCRV that further translated to native wild-and NWAs, including LASV, JUNV and MACV, in pseudotyped virus assays and against native replicative LASV and JUNV.ARN-75039 also potently inhibits mutant T434I pTCRV variant with EC50 of 29 nM.ARN-75039 dramatically improved survival outcome and potently inhibited TCRV replication in serum and various tissues at doses of 10 and 35 mg/kg, provided highly significant post-exposure protection in mice against TCRV infection. |
|---|---|
| References | 1. Brian B Gowen, et al. Antiviral Res. 2021 Sep;193:105125. 2. Michael B Plewe, et al. Bioorg Med Chem Lett. 2021 Jun 1;41:127983. |
| Molecular Formula | C27H30N2O2 |
|---|---|
| Molecular Weight | 414.549 |