2408477-50-7
2408477-50-7 structure
- Name: KS106
- Chemical Name: KS106
- CAS Number: 2408477-50-7
- Molecular Formula: C18H15BrF3N3O2S
- Molecular Weight: 474.29
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2022-07-02 11:08:52
- Modify Date: 2024-01-13 14:58:20
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KS106 is a potent ALDH inhibitor with IC50s of 334, 2137, 360 nM for ALDH1A1, ALDH2, and ALDH3A1, respectively. KS106 shows antiproliferative and anticancer effects with low low toxic.KS106 significantly increases ROS activity, lipid peroxidation and toxic aldehyde accumulation. KS106 induces apoptosis and cell cycle arrest at the G2/M phase[1].
| Name | KS106 |
|---|
| Description | KS106 is a potent ALDH inhibitor with IC50s of 334, 2137, 360 nM for ALDH1A1, ALDH2, and ALDH3A1, respectively. KS106 shows antiproliferative and anticancer effects with low low toxic.KS106 significantly increases ROS activity, lipid peroxidation and toxic aldehyde accumulation. KS106 induces apoptosis and cell cycle arrest at the G2/M phase[1]. |
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| Related Catalog | |
| Target |
IC50: 334 nM (ALDH1A1); 2137 nM (ALDH2); 360 nM (ALDH3A1)[1] |
| In Vitro | KS106 (compound 3h) (0-100 µM; 72 h) shows anti-proliferative activity with IC50s of 5.7, 5.7, 5.7, 4.9, 1.5, 2.6, 1.6, 1.7, 2.2, 20.7 µM for UACC 903, 1205 Lu, HCT116, HT29, NCIH929, U266, RPMI8226, MM.1R, MM.1S, FF2441 cells, respectively[1]. KS106 (5 µM, 24 h) induces apoptosis and cell cycle arrest at the G2/M phase[1]. Apoptosis Analysis[1] Cell Line: HCT116, HT29 cells Concentration: 5 µM Incubation Time: 24 h Result: Induced cell apoptosis. Cell Cycle Analysis[1] Cell Line: HCT116 cells Concentration: 5 µM Incubation Time: 24 h Result: Induced cell cycle arrest at G2/M phase. |
| References |
| Molecular Formula | C18H15BrF3N3O2S |
|---|---|
| Molecular Weight | 474.29 |