1310012-12-4

1310012-12-4 structure

Name: VU0360172
Chemical Name: VU0360172
CAS Number: 1310012-12-4
Molecular Formula: C₁₈H₁₅FN₂O
Molecular Weight: 294.32
Catalog: Signaling Pathways GPCR/G Protein mGluR
Create Date: 2022-08-14 19:01:17
Modify Date: 2024-01-02 17:58:08
VU0360172 is a potent and selective mGlu5 receptor positive allosteric modulator with an EC50 value of 16 nM and a Ki of 195 nM, respectively. VU0360172 stimulates polyphosphoinositide (PI) hydrolysis in vivo, which is abrogated in mGlu5 receptors gene deleted mice[1].

Name	VU0360172

Description	VU0360172 is a potent and selective mGlu5 receptor positive allosteric modulator with an EC50 value of 16 nM and a Ki of 195 nM, respectively. VU0360172 stimulates polyphosphoinositide (PI) hydrolysis in vivo, which is abrogated in mGlu5 receptors gene deleted mice[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> mGluR Research Areas >> Neurological Disease
Target	EC50: 16 nM (mGlu5 receptor)[1] Ki: 195 nM (mGlu5 receptor)[1]
References	[1]. Zuena AR, et al. In Vivo Non-radioactive Assessment of mGlu5 Receptor-Activated Polyphosphoinositide Hydrolysis in Response to Systemic Administration of a Positive Allosteric Modulator. Front Pharmacol. 2018 Jul 31;9:804.

Molecular Formula	C₁₈H₁₅FN₂O
Molecular Weight	294.32