2259860-24-5

2259860-24-5 structure

Name: Zimberelimab
Chemical Name: Zimberelimab
CAS Number: 2259860-24-5
Molecular Formula:
Molecular Weight:
Catalog: Signaling Pathways Immunology/Inflammation PD-1/PD-L1
Create Date: 2022-08-03 19:59:56
Modify Date: 2024-01-10 21:24:34
Zimberelimab is a fully human IgG4 anti-PD-1 monoclonal antibody with high affinity and selectivity. Zimberelimab shows antitumor activities and can be used for various cancers research including cervical cancer, non-small cell lung cancer and classical Hodgkin’s lymphoma[1].

Name	Zimberelimab

Description	Zimberelimab is a fully human IgG4 anti-PD-1 monoclonal antibody with high affinity and selectivity. Zimberelimab shows antitumor activities and can be used for various cancers research including cervical cancer, non-small cell lung cancer and classical Hodgkin’s lymphoma[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> PD-1/PD-L1
In Vitro	Zimberelimab has an EC50 of 210 pM for human PD-1 but does not bind to related CD28 family receptors, such as ICOS, CD28 and CTLA-4[1]. Zimberelimab binding to cell-expressed human PD-1 inhibits the interaction of the receptor with both human PD-L1 and PD-L2 with IC50s of 580 pM and 670 pM, respectively[1]. Zimberelimab dose-dependently enhances IFN-g production and proliferation by CD4+ T cells, saturating at concentrations below 100 pM[1].
References	[1]. Markham A. Zimberelimab: First Approval. Drugs. 2021 Nov;81(17):2063-2068. [2]. Lou B, et al. Preclinical Characterization of GLS-010 (Zimberelimab), a Novel Fully Human Anti-PD-1 Therapeutic Monoclonal Antibody for Cancer. Front Oncol. 2021 Sep 15;11:736955.

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