912790-59-1
912790-59-1 structure
- Name: Wnt/β-catenin agonist 3
- Chemical Name: 3-Isoxazolecarboxamide, 5-(4-chlorophenyl)-N-[3-(1H-imidazol-1-yl)propyl]-
- CAS Number: 912790-59-1
- Molecular Formula: C16H15ClN4O2
- Molecular Weight: 330.77
- Catalog: Research Areas Cardiovascular Disease
- Create Date: 2022-09-12 22:57:56
- Modify Date: 2024-01-20 22:11:45
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Wnt/β-catenin agonist 3 (compound 98) is a Wnt/β-catenin signalling pathway agonist. Wnt/β-catenin agonist 3 can be used for the research of osteoporosis[1].
| Name | 3-Isoxazolecarboxamide, 5-(4-chlorophenyl)-N-[3-(1H-imidazol-1-yl)propyl]- |
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| Description | Wnt/β-catenin agonist 3 (compound 98) is a Wnt/β-catenin signalling pathway agonist. Wnt/β-catenin agonist 3 can be used for the research of osteoporosis[1]. |
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| Related Catalog | |
| In Vitro | Wnt/β-catenin agonist 3 (compound 98; 24 h; HEK293 and SW480 cells) has 54% cell activity at 120 μM concentration compared with the positive control group LiCl (20mM)[1]. Wnt/β-catenin agonist 3 (30 and 60 μM; 24 h; HEK293 cells) is an activator for β-Catenin and deposits β-catenin[1]. Wnt/β-catenin agonist 3 (11 μM; 4 d) induces differentiation of ST2 cell line into osteoblasts and calcium deposition[1]. Western Blot Analysis[1] Cell Line: HEK293 cells Concentration: 30 and 60 μM Incubation Time: 24 hours Result: Deposited β-catenin in a dose-dependent pattern within cells. |
| References |
[1]. Cho JW, et al. Isoxazole derivatives and use thereof. WO2007078113A1. |
| Molecular Formula | C16H15ClN4O2 |
|---|---|
| Molecular Weight | 330.77 |
| Storage condition | 2-8°C |