2260905-08-4

2260905-08-4 structure

Name: Tauro-α-muricholic acid sodium
Chemical Name: Tauro-α-muricholic Acid (sodium salt)
CAS Number: 2260905-08-4
Molecular Formula: C₂₆H₄₄NNaO₇S
Molecular Weight: 537.68
Catalog: Signaling Pathways Metabolic Enzyme/Protease FXR
Create Date: 2022-11-08 22:49:11
Modify Date: 2024-04-05 19:05:27
Tauro-α-muricholic acid (T-α-MCA) sodium is a FXR (Farnesoid X receptor) antagonist (IC50=28μM). Tauro-α-muricholic acid sodium is also a endogenous metabolite that can be found in cecal[1][2].

Name	Tauro-α-muricholic Acid (sodium salt)
Synonyms	Sodium 2-{[(3α,5β,6β)-3,6,7-trihydroxy-24-oxocholan-24-yl]amino}ethanesulfonate Ethanesulfonic acid, 2-[[(3α,5β,6β)-3,6,7-trihydroxy-24-oxocholan-24-yl]amino]-, sodium salt (1:1)

Description	Tauro-α-muricholic acid (T-α-MCA) sodium is a FXR (Farnesoid X receptor) antagonist (IC50=28μM). Tauro-α-muricholic acid sodium is also a endogenous metabolite that can be found in cecal[1][2].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> FXR Research Areas >> Others
Target	Microbial Metabolite
References	[1]. Chen W, et al. Farnesoid X receptor is inhibited after ileum transposition in diabetic rats: its hypoglycemic effect. Int J Med Sci. 2023 Apr 2;20(5):595-605. [2]. Ye X, et al. Sodium butyrate alleviates cholesterol gallstones by regulating bile acid metabolism. Eur J Pharmacol. 2021 Oct 5;908:174341.

Molecular Formula	C₂₆H₄₄NNaO₇S
Molecular Weight	537.68
Exact Mass	537.273621
Appearance	A crystalline solid
Storage condition	-20°C
Water Solubility	DMF: 10 mg/mL ; DMSO: 10 mg/mL ; Ethanol: 1 mg/mL