331968-10-6

331968-10-6 structure

Name: sRANKL-IN-1
Chemical Name: sRANKL-IN-1
CAS Number: 331968-10-6
Molecular Formula: C₁₈H₁₈N₄O₆S
Molecular Weight: 418.42
Catalog: Research Areas Inflammation/Immunology
Create Date: 2022-10-14 13:10:45
Modify Date: 2024-04-05 18:23:59
sRANKL-IN-1 (compound S3) is a sRANKL (soluble RANKL) inhibitor. sRANKL-IN-1 shows a potent osteoclast inhibition effect with an IC50 value of 0.096 μM and a KD value of 34.80 μM. sRANKL-IN-1 can be used for the research of osteoporosis[1].

Name	sRANKL-IN-1

Description	sRANKL-IN-1 (compound S3) is a sRANKL (soluble RANKL) inhibitor. sRANKL-IN-1 shows a potent osteoclast inhibition effect with an IC50 value of 0.096 μM and a KD value of 34.80 μM. sRANKL-IN-1 can be used for the research of osteoporosis[1].
Related Catalog	Research Areas >> Inflammation/Immunology
Target	IC50: 0.096 μM (osteoclast)[1]
In Vitro	sRANKL-IN-1 (0-50 μM) shows potent inhibition to osteoclast[1]. Cell Viability Assay[1] Cell Line: Bone marrow cell line Concentration: 0-50 μM Incubation Time: Until osteoclasts formed Result: Inhibited osteoclasts formation with an IC50 value of 0.096 μM and a KD value of 34.80 μM.
References	[1]. Huang D, et al. Identification of a binding site on soluble RANKL that can be targeted to inhibit soluble RANK-RANKL interactions and treat osteoporosis. Nat Commun. 2022 Sep 12;13(1):5338.

Molecular Formula	C₁₈H₁₈N₄O₆S
Molecular Weight	418.42