286008-51-3

286008-51-3 structure

Name: RDR03871
Chemical Name: 1,2-Ethanediamine, N1-[5-chloro-6-methyl-2-(2-pyridinyl)-4-pyrimidinyl]-N2-[6-(trifluoromethyl)-2-pyridinyl]-
CAS Number: 286008-51-3
Molecular Formula: C₁₈H₁₆ClF₃N₆
Molecular Weight: 408.81
Catalog: Signaling Pathways Apoptosis MDM-2/p53
Create Date: 2022-10-28 00:42:44
Modify Date: 2024-01-01 13:26:06
RDR03871 (compound 2) is a potent dual MDM2/MDM4 inhibitor with IC50 values of 35.4 nM and 10.4 nM for MDM2-p53 and MDM4-p53, respectively[1].

Name	1,2-Ethanediamine, N1-[5-chloro-6-methyl-2-(2-pyridinyl)-4-pyrimidinyl]-N2-[6-(trifluoromethyl)-2-pyridinyl]-

Description	RDR03871 (compound 2) is a potent dual MDM2/MDM4 inhibitor with IC50 values of 35.4 nM and 10.4 nM for MDM2-p53 and MDM4-p53, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Apoptosis >> MDM-2/p53
References	[1]. Mariateresa Giustiniano, et al. Computer-Aided Identification and Lead Optimization of Dual Murine Double Minute 2 and 4 Binders: Structure-Activity Relationship Studies and Pharmacological Activity. J Med Chem. 2017 Oct 12;60(19):8115-8130.

Molecular Formula	C₁₈H₁₆ClF₃N₆
Molecular Weight	408.81