881191-44-2
881191-44-2 structure
- Name: Otelixizumab
- Chemical Name: Otelixizumab
- CAS Number: 881191-44-2
- Molecular Formula:
- Molecular Weight:
- Catalog: Research Areas Metabolic Disease
- Create Date: 2022-11-12 17:24:51
- Modify Date: 2024-01-10 15:43:36
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Otelixizumab (ChAglyCD3) is an anti-human CD3 monoclonal antibody and can be used for the research of type 1 diabetes[1].
| Name | Otelixizumab |
|---|
| Description | Otelixizumab (ChAglyCD3) is an anti-human CD3 monoclonal antibody and can be used for the research of type 1 diabetes[1]. |
|---|---|
| Related Catalog | |
| Target |
CD3[1] |
| In Vitro | Otelixizumab (ChAglyCD3) has a dose-dependent accumulation and a half-life of about 1.5 days[2]. Otelixizumab targets the ε-chain of the CD3 T-lymphocyte surface receptor, which facilitates the activation of the autoreactive T-lymphocytes responsible for beta cell destruction[2]. |
| In Vivo | Otelixizumab (ChAglyCD3) (100 μg/mouse; i.v.; once) results in durable disease remission dependent on transferable T cell–mediated tolerance in diabetic transgenic mice[1]. Animal Model: BALB/c-huCD3e mice carrying the human CD3e chain[1] Dosage: 100 μg/mouse Administration: Intravenous injection, once Result: Induced secretion of lower amounts of IL-6. Exhibited up-regulation of regulatory T cells. |
| No Any Chemical & Physical Properties |