2407227-31-8
2407227-31-8 structure
- Name: NITD-688
- Chemical Name: NITD-688
- CAS Number: 2407227-31-8
- Molecular Formula: C25H32N4O3S2
- Molecular Weight: 500.68
- Catalog: Research Areas Infection
- Create Date: 2022-12-15 18:55:18
- Modify Date: 2024-04-10 01:17:44
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NITD-688 is an orally active pan-serotype inhibitor of the dengue virus NS4B protein. NITD-688 can be used in the research of dengue virus (DENV)[1].
| Name | NITD-688 |
|---|
| Description | NITD-688 is an orally active pan-serotype inhibitor of the dengue virus NS4B protein. NITD-688 can be used in the research of dengue virus (DENV)[1]. |
|---|---|
| Related Catalog | |
| Target |
NS4B[1] |
| In Vitro | NITD-688 shows antiviral activity against all four serotypes of dengue virus (DENV), with EC50 values of 8 to 38 nM[1]. NITD-688 shows antiviral activity against DENV-2 infected PBMCs, with an EC50 value of 0.94 nM[1]. NITD-688 directly binds to wild-type but not mutant NS4B protein[1]. |
| In Vivo | NITD-688 (30 mg/kg, oral gavage, twice daily for 3 days) demonstrates excellent antiviral efficacy in infected AG129 mice[1]. NITD-688 (15-300 mg/kg, oral gavage, per day for 7 days) is well tolerated in rats and dogs (toxicology studies)[1]. Animal Model: Infected AG129 mice[1] Dosage: 30 mg/kg Administration: Oral gavage, twice daily for 3 days Result: Resulted in a 1.16-log reduction in viremia. |
| Molecular Formula | C25H32N4O3S2 |
|---|---|
| Molecular Weight | 500.68 |