2516243-54-0
2516243-54-0 structure
- Name: Adintrevimab
- Chemical Name: Adintrevimab
- CAS Number: 2516243-54-0
- Molecular Formula:
- Molecular Weight:
- Catalog: Signaling Pathways Anti-infection SARS-CoV
- Create Date: 2023-01-18 15:50:48
- Modify Date: 2024-01-12 12:33:54
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Adintrevimab (ADG 20) is a human IgG1 monoclonal SARS-CoV (SARS-CoV) antibody. Adintrevimab inhibits SARS-CoV-2 variants and other SARS-like coronaviruses with pandemic potential[1].
| Name | Adintrevimab |
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| Description | Adintrevimab (ADG 20) is a human IgG1 monoclonal SARS-CoV (SARS-CoV) antibody. Adintrevimab inhibits SARS-CoV-2 variants and other SARS-like coronaviruses with pandemic potential[1]. |
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| Related Catalog | |
| In Vitro | Adintrevimab 的 Fc 片段区域经过修饰以延长其半衰期。 Adintrevimab 与 SARS-CoV-2 刺突糖蛋白受体结合域中的一个独特表位结合，该表位与血管紧张素转换酶 2 结合位点部分重叠，在 sarbecoviruses 中高度保守。在体外，Adintrevimab 已证明对 SARS-CoV-2（包括 Alpha、Beta、Gamma 和 Delta）的大多数变体和亚系以及其他 SARS 样病毒具有有效的中和活性。Adintrevimab 对 Omicron BA.1/BA.1.1 的体外活性降低，对 BA.2、BA.3、BA.4 和 BA.5 缺乏活性[1]。 |
| In Vivo | Adintrevimab（9.25、55、333 或 2,000μg；腹腔注射；一次）以剂量依赖性方式提供针对 SARS-CoV-2/WA1/2020 感染的保护[1]。 Adintrevimab（5-25mg/kg；静脉注射；一次）以剂量依赖性方式提供针对 SARS-CoV-2/WA1/2020 感染的保护[1]。 Animal Model: Syrian golden hamsters (5-6-week-old females; 75-125 g) infected with SARS-CoV-2/WA1/2020[1]. Dosage: 9.25, 55, 333, or 2,000 μg (average range: 0.1 to 20 mg/kg) Administration: Intraperitoneal injection; single dose Result: Showed significant reduction in lung viral load and virus-induced lung pathology. Animal Model: Rhesus macaques (5.6-8.8 years old; 6 females [4.4-6.3 kg] and 6 males [6.1-8.5 kg]) infected with SARS-CoV-2/WA1/2020[1]. Dosage: 5 mg/kg, 25 mg/kg Administration: Intravenous injection; single dose Result: Reduced pulmonary inflammation. |
| References |
| No Any Chemical & Physical Properties |