2375952-29-5
2375952-29-5 structure
- Name: Ansuvimab
- Chemical Name: Ansuvimab
- CAS Number: 2375952-29-5
- Molecular Formula:
- Molecular Weight:
- Catalog: Signaling Pathways Anti-infection Filovirus
- Create Date: 2023-02-03 11:47:30
- Modify Date: 2024-09-12 18:02:28
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Ansuvimab (Ansuvimab-zyk) is a recombinant human monoclonal IgG1 antibody that exhibits antiviral activity against Zaire ebolavirus. Ansuvimab binds to the glycoprotein on Zaire ebolavirus to block its entry into host cells[1].
| Name | Ansuvimab |
|---|
| Description | Ansuvimab (Ansuvimab-zyk) is a recombinant human monoclonal IgG1 antibody that exhibits antiviral activity against Zaire ebolavirus. Ansuvimab binds to the glycoprotein on Zaire ebolavirus to block its entry into host cells[1]. |
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| Related Catalog | |
| Target |
Zaire ebolavirus[1] |
| In Vitro | Ansuvimab 通过结合位于埃博拉病毒糖蛋白 (GP) 的 GP1 亚基受体结合位点的 LEIKKPDGS 表位来阻断 GP 与 Niemann-Pick C1 受体之间的结合[1]。 Ansuvimab 对转染 GP 的靶细胞具有抗体依赖性细胞毒性 (ADCC)，在浓度为 0.03 μg/mL 时具有最大活性[3]。 |
| In Vivo | Ansuvimab 给药使所有猕猴在第 0 天暴露于致死剂量的埃博拉病毒后存活下来[1]。 |
| References |
[1]. Lee A, et, al. Ansuvimab: First Approval. Drugs. 2021 Apr;81(5):595-598. |
| No Any Chemical & Physical Properties |